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Medical > Therapy > Specific treatments

Prostanoids History

 

Almost seventy years ago, von Euler discovered and named the prostaglandins (Von Euler 1936). Prostaglandins are a group of lipid compounds of specific structure derived from arachidonic acid, which are present in almost every tissue and body fluid. To date, more than 100 prostaglandins with different structures have been detected, but some of them, while identified chemically, as yet do not have any known biologic function. Whereas prostaglandin E1 (PGE1) was the first prostaglandin to be isolated in pure form (Bergstrom et al. 1957), prostacyclin (PGI2) was one of the last substances to be discovered from this group (Moncada et al. 1976). In 1982, Bergstrom, Samuelsson and Vane were awarded by the Nobel Prize for their discoveries concerning prostaglandins and related biologically active substances.

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