Oxygen therapy
Medical > Therapy > Basic treatments
Oxygen therapy
The goal of supplemental oxygen therapy is to inhibit hypoxic pulmonary vasoconstriction. Supplemental oxygen improves remarkably symptoms and signs associated with high altitude pulmonary edema and decreases pulmonary artery pressure acutely by approximately 10 percent (Groves et al., 1987, Maggiorini et al., 2001). In patients with pulmonary hypertension associated with obstructive lung disease, acute hyperoxia decreased pulmonary artery pressure and improved blood oxygenation (Saadjian et al., 1992). During a follow-up period of 3 years, nocturnal nasal oxygen therapy was shown to decrease pulmonary artery pressure on average by 4 mmHg, but compared to sham-treated patients did not improve survival. However, mortality was higher in patients with nocturnal desaturation (SaO2 < 60 mmHg) (Fletcher et al., 1992). There are no data showing that long-term supplemental oxygen is beneficial in pulmonary hypertension with or without hypoxemia. Conversely, combined inhalation of oxygen and nitric oxide decreased pulmonary vascular resistance in patients with intracardiac shunts (Turanlahti et al., 1998) and improved gas exchange in COPD patients (Yoshida et al., 1997) more than inhalation of nitric oxide without supplemental oxygen. Thus, supplemental oxygen therapy is recommended in cases in which pulmonary hypertension is associated with hypoxemia at rest due to lung disease, thromboembolism, intracardiac right-left shunt or exercise-induced significant blood oxygen desaturation.
References
Back to > Medical > Therapy > Basic treatments
Oxygen therapy
The goal of supplemental oxygen therapy is to inhibit hypoxic pulmonary vasoconstriction. Supplemental oxygen improves remarkably symptoms and signs associated with high altitude pulmonary edema and decreases pulmonary artery pressure acutely by approximately 10 percent (Groves et al., 1987, Maggiorini et al., 2001). In patients with pulmonary hypertension associated with obstructive lung disease, acute hyperoxia decreased pulmonary artery pressure and improved blood oxygenation (Saadjian et al., 1992). During a follow-up period of 3 years, nocturnal nasal oxygen therapy was shown to decrease pulmonary artery pressure on average by 4 mmHg, but compared to sham-treated patients did not improve survival. However, mortality was higher in patients with nocturnal desaturation (SaO2 < 60 mmHg) (Fletcher et al., 1992). There are no data showing that long-term supplemental oxygen is beneficial in pulmonary hypertension with or without hypoxemia. Conversely, combined inhalation of oxygen and nitric oxide decreased pulmonary vascular resistance in patients with intracardiac shunts (Turanlahti et al., 1998) and improved gas exchange in COPD patients (Yoshida et al., 1997) more than inhalation of nitric oxide without supplemental oxygen. Thus, supplemental oxygen therapy is recommended in cases in which pulmonary hypertension is associated with hypoxemia at rest due to lung disease, thromboembolism, intracardiac right-left shunt or exercise-induced significant blood oxygen desaturation.
References
Back to > Medical > Therapy > Basic treatments
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SSPH Research Prize 2012
Deadline for submission: April 30, 2012
Further information
Symposium "pulmonal-arterielle Hypertension im Kindesalter"
Donnerstag, 10. Mai 2012, 16.00-18.00, Bern
Further information:
5th International Congress of the Swiss Society of Pulmonary Hypertension (SSPH)
28.-29. September 2012, Thun, Congress Hotel Seepark Thun
Informationen: www.imk.ch/sgph2012
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