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Endothelin receptor antagonists
Randomized controlled trials of oral endothelin receptor antagonists

Trial	Channick  et al. 2001	Rubin  et al. 2002	Barst  et al. 2002
Prostanoid	Bosentan	Bosentan	Sitaxsentan
Patients (n)	32	213	178
Etiology of PH  IPAH / CTD / CHD  CTEPH / HIV / PPHTN	85 / 15 / 0  0 / 0 / 0	70 / 30 / 21  0 / 0 / 0	53 / 24 / 24  0 / 0 / 0
NYHA II / III / IV	0 / 100 / 0	91 / 9 / 0	33 / 66 / 1
Duration (m)	3	4	3
Primary endpoint	6-MW  + NYHA	6-MW	Peak VO2
Improvement  in 6-MW (m)  compared to  controls	+76	+44	+34
Improvement in  other enpoints	Hemodyn,  NYHA  Clinical events	NYHA  Clinical events	-
Sideeffects (n)	Elevated  transaminases	Elevated  transaminases	Elevated  transaminases

References

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