Beta-blockers
Medical > Therapy > General measures
Betablockers
Beta-receptors are involved in the regulation of the pulmonary vascular tone and myocardial contractility. In acute hypoxia, beta-blockers increase pulmonary vascular tone (Brimioulle et al., 1997). In patients with severe mitral stenosis, beta-blockade increases pulmonary vascular resistance despite a decrease in left atrial pressure, cardiac output and systemic blood pressure (Wisenbaugh et al., 1993). Thus, beta-blockers have not only a negative inotropic effect on the myocardium, but they may also impair coronary perfusion pressure by lowering the systemic blood pressure. Therefore, beta-blockers should be avoided in pulmonary hypertension.
References
Back to > Medical > Therapy > General measures
Betablockers
Beta-receptors are involved in the regulation of the pulmonary vascular tone and myocardial contractility. In acute hypoxia, beta-blockers increase pulmonary vascular tone (Brimioulle et al., 1997). In patients with severe mitral stenosis, beta-blockade increases pulmonary vascular resistance despite a decrease in left atrial pressure, cardiac output and systemic blood pressure (Wisenbaugh et al., 1993). Thus, beta-blockers have not only a negative inotropic effect on the myocardium, but they may also impair coronary perfusion pressure by lowering the systemic blood pressure. Therefore, beta-blockers should be avoided in pulmonary hypertension.
References
Back to > Medical > Therapy > General measures
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SSPH Research Prize 2012
Deadline for submission: April 30, 2012
Further information
Symposium "pulmonal-arterielle Hypertension im Kindesalter"
Donnerstag, 10. Mai 2012, 16.00-18.00, Bern
Further information:
5th International Congress of the Swiss Society of Pulmonary Hypertension (SSPH)
28.-29. September 2012, Thun, Congress Hotel Seepark Thun
Informationen: www.imk.ch/sgph2012
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